Synthesis and Evaluation of Antihyperglycemic Activity of 1, 4-Benzothiazepine-2-One Derivatives in Alloxan Induced Diabetic Rats

The present study reported the synthesis and antihyperglycemic activity of 1,4-benzothiazepines (1,4-benzothiazepine-2-one derivatives) in alloxan-induced diabetic rats. (3a-i) were synthesized via Friedel-Crafts acylation, reduction microwave assisted S-alkylation reactions characterized by Fourier transform infrared spectroscopy, proton nuclear magnetic resonance, mass elemental analysis. In silico absorption, distribution, metabolism, excretion toxicity parameters compounds 3a-i found within their acceptable limits. acute study, none showed any risks such as tremor, convulsion, lacrimation, sedation, increased or decreased motor activity, etc., Wistar that reduced elevated blood glucose level significantly 3f, 3h 3i with electronegative substitution at 7 position benzothiazepine nucleus 2’ phenyl ring, better compared to other having weak substituent same position. was comparable metformin CGP37157. may be helpful development novel antidiabetic agents.